The NanoBio Brown Lab at the University of Central Florida in the Department of Materials Scinece and Engineering launched Fall 2024! The NanoBio lab is centered around understanding and leveraging inherent material-biological interactions to design next-generation nanomaterial drug delivery systems.
The NanoBio Lab in collaboration with the Sridhar lab was just awarded a MLSC Women’s Health Innovation award for “InCITE: A Biomaterial Platform to Overcome Barriers to Drug Delivery” with the goal to translate our technology to help women with ovarian cancer. (Read more)
Congratulations Shicheng Yang for receiving the Lux. Veritas. Virtus award! The Lux. Veritas. Virtus. society, a prestigious honor that recognizes exceptional graduate students who exemplify the university’s mission, ideals, and values. (Read more
Shicheng Yang
Check out our new publication in Cancer Nanotechnology on the formulation of a nano-cocktail of talazoparib and dinaciclib for the treatment of breast cancer.
Check out the article!
Check out our new publication in Nanoscale on AGuIX-nanobody bioconjugates via two advanced biofunctionalization pathway (sortagging and click chemistry) as an MRI contrast agent for in patient immune check point tracking.
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Check out this cool article by Northeastern Global News! It showcases our research on formulation nano/bio solutions for breast and ovarian cancer.
The NanoBio Lab undergraduate research assistants, Julia Treese & Jillian Jurczyszak, have just been awarded Spring 2024 Project-Based Exploration for the Advancement of Knowledge (PEAK) Summit Awards to continue their work in the NanoBio Lab!
Julia Treese: Characterization of STING Agonist Implants for Combination Treatment of BRCA-Mutated Cancers (Read more)
Jillian Jurczyszak: Drug Release Kinetics of Talazoparib in an Immunocompetent BRCA-Deficient Ovarian Cancer Model
Julia Treese
Jillian Jurczyszak
Rupsa Jana will be joining the NanoBio Lab as an AJC Research Merit Scholar this Spring 2024 for her second co-op. AJC Merit Research Scholarship which is given to 3% of the top STEM undergraduate researchers at Northeastern University who demonstrate exemplary potential for broad scope research impact within the scientific community as well as potential as strong ambassadors for their field of study. Rupsa’s project will focus on “Lipid Nanoformulations for STING-agonist Delivery in Conjunction to PARPi Therapy for BRCA-deficient.” Read more
Rupsa Jana
The NanoBio Lab undergraduate research assistant, Julia Treese, has just been awarded a Project-Based Exploration for the Advancement of Knowledge (PEAK) Shout-It-Out award to support her presentation at the annual American Institute of Chemical Engineers (AIChE) conference in Orlando, FL to present her work on “Formulation and Characterization of STING Agonists Implants to Overcome Barriers to Delivery” Check out the abstract
Check out our new publication in Theranostics on the formulation of second generation bismuth-gadolinium nanoparticles to improve radiosensitization while maintaining MRI contrast.
Check out the article!
The NanoBio Lab was just awarded a CDMRP Breast Cancer Resarch Program Breakthrough Level II award with Partnering-PI, Jennifer Guerriero, at Brigham and Women’s Hospital to develop “Sustained release STING agonist implants activate antitumor immunity to treat advanced breast cancer in combination with PARPi”. The objective of this work is to generate preclinical data that will provide a strong rationale for a sustained STING agonist delivery method that is the major breakthrough necessary for clinical translation of STING agonist as a curative strategy for advanced, metastatic breast cancer.
The NanoBio Lab was just awarded a CDMRP Ovarian Cancer Resarch Program Pilot Award award with Co-Investigator, Srinivas Sridhar, at Northeastern University to develop “Combination Intraperitoneal Local Delivery of PARPi Implants and Anti-PDL1”. The proposed study seeks to develop effective combinations of sustained release TLZ implants with immunomodulatory factors, anti-PDL1 and STING agonist, to overcome PARPi resistance and minimize systemic toxicity in a patient-mimicking, peritoneal metastatic high grade serous ovarian cancer model.
The NanoBio Lab was just awarded a Dana-Farber/Harvard Cancer Center Breast Cancer SPORE Career Enhacement Award (CEP). The purpose of the CEP is to help develop the careers of young investigators committed to breast cancer, and support the awardees’ efforts to become independent researchers.
Check out our new publication in Frontiers in Oncology on the formulation of sustained release PLGA implants for the talazoparib as a means to aleviate drug induced toxicity and improve tumor specific dose.
Check out the article!
NanoBio Lab
Contact
Address: 6900 Lake Nona Blvd, BBS 457, Orlando, FL 32827
Email: needa.brown@ucf.edu
Phone: 407-266-7138
© Copyright 2024 Needa Brown